Product Line

ENDONEXT
The evolution in Endotoxin Detection
Leaders in endotoxin analysis with recombinant technology.

One of the main goals is to innovate in endotoxin detection while protecting the patient. ENDONEXT ™ endotoxin detection assays based on recombinant factor C (rFC), present in horseshoe crab, provide the performance needed for speed and efficiency during in-process control, product release, and solutions for the most complex matrices during the manufacturing process. The use of synthetic rFC instead of horseshoe crab blood cell-based not only ensures ecological sustainability and supply reliability, but also provides unprecedented accuracy, sensitivity, and batch-to-batch uniformity.

Key benefits:
● 100% endotoxin specificity, with no false positive results due to ß-glucans or interference caused by cloudy or colored samples.
● Approved for use and validated in the same way as LAL (Limulus Amebocyte Lysate), following the BET (Bacterial Endotoxin Test) sections of the Pharmacopoeia.
● Increased accuracy and rate of valid results with time savings and batch-to-batch uniformity. BioMérieux is delivering faster, simpler, and more environmentally friendly endotoxin tests by mimicking nature rather than abusing it. These tests allow for safe in-process control and decision-making regarding the release of pharmaceutical products and medical devices.
The ENDONEXT ™ range, time and cost saving methods:
ENDOZYME® II GO
Therapid GO version of ENDOZYME®II features GOPLATE ™, a pre-filled microplate with the required standard curve and positive product control concentrations. (PPC).
• Eliminates manual preparation of PPC standard dilutions
• More than 50% reduction of handling time with respect to conventional microplates assays
• Significantly reduces the risk of handling error
• Ideal for in-process control of water and raw materials, as well as analysis for product release
• Easy automation
ENDOZYME® II
The optimized second generation ENDOZYME® is a flexible and easy-to-use assay for endotoxin detection
• State-of-the-art sensitivity below 0.001 EU / ml
• Flexible titration time according to required sensitivity
• Particularly suitable for end-product analysis, formulation, and research
ENDOLISA®
With a single integrated sample preparation step, the ENDOLISA® assay revolutionizes endotoxin analysis of complex samples.
• The ELISA-like format features a precoated 96-well plate with a specific endotoxin-binding protein found in bacteriophages.
• Exceeds the limits of traditional methods such as inhibition and amplification
• Unprecedented tolerance to detergents and organic solvents

Portfolio

BIOMERIEUX
• ENDONEXT®

Catalogs

ENDONEXT

ENDOZIME II

ENDOZIME II GO

ENDOLISA